Maibritt saerens biography sampler

Poster Presentations

(ADCC/CDC)

P1 The identification of potent anti-tumor antibodies for ADC therapeutics from patients undergoing immunotherapy

Alexander Scholz, PhD, Jerald Aurellano, Michael Harbell, MS PhD, Danhui Zhang, MD PhD, Samantha O'Connor, May Sumi, BS, Beatriz Millare, BS, Felix Chu, MS, Sheila Fernandez, Cathrin Czupalla, Iraz Aydin, PhD, Amy Manning-Bog, PhD, Yvonne Leung, BS, PhD, Kevin Williamson, BS PhD, Chantia Carroll, Dongkyoon Kim, BS PhD, Xiaomu Chen, MS PhD, Sean Carroll, BS, PhD, Ish Dhawan, PhD, Ngan Nguyen, BS PhD, Shweta Thyagarajan, Mark Whidden, Gregg Espiritu Santo, BS PhD, Nicole Haaser, MS, Hibah Mahmood, Guy Cavet, PhD, Lawrence Steinman, MD, Tito Serafini, PhD, Wayne Volkmuth, BS PhD, Jonathan Benjamin, MD, PhD, William Robinson, MD, Norman Greenberg, PhD, Daniel Emerling, PhD, Jell DeFalco

Atreca Inc, Redwood City, CA, USA; Stanford University School of Medicine, Stanford, CA, USA

Correspondence: Daniel Emerling (d.emerling@atreca.com)

Background

Anti-tumor therapy with antibody-drug conjugates (ADCs) is predicated on the identification of antibodies that demonstrate suitable selectivity for tumor cells that are also internalized upon binding their cognate target. Remarkably, only a select number of such antibodies with the propensity to internalize have been identified, limiting the range and breadth of ADC therapeutics in the clinic. Here we show that Atreca’s Immune Repertoire Capture (IRC™) technology can identify potent anti-tumor antibodies with internalization activity applicable for ADC therapeutics from patients undergoing immunotherapy.

Methods

We analyzed blood plasmablasts from patients with non-progressing metastatic cancer using IRC™ technology. Briefly, plasmablasts were collected from p

Giorgio Armani is waiting, talking Italian. Mr Armani – as he is always referred to, across multiple languages – doesn’t wait very often. He isn’t able to, given his empire complex, with brand revenues totalling €4.2 billion (£3.5bn) in 2019, which spans such esoteric delights as Armani homewares and hotels, floristry and chocolates. Of course, what Mr Armani is best known for is fashion: his eponymous label, Giorgio Armani, founded in 1975; Armani Privé, his range of made-to-measure haute couture clothing for women, shown in Paris since 2005; and Emporio Armani. 

\If Giorgio Armani is the purest distillation of Armani’s aesthetic ideology and Privé is his extravagant, exuberant and indulgent side – as clothes costing upwards of £30,000 have a tendency to be – Emporio represents a youthful esprit, despite the fact it turns 40 this year. The line will be celebrated, come autumn, with a show at Silos, Armani’s minimalist Milanese exhibition space, Emporio outfits framed by photography that helps cement Armani’s vision, his universe. It is rare to get him to pause.

When he does so, for GQ, it is in Paris. He has just met privately with the Italian president, Sergio Mattarella – fitting given that Armani is Italian fashion’s elder statesman. They discussed the state of the economy, of the industry. Mattarella’s daughter, Laura, attended Armani’s haute couture presentation held at the Italian embassy in Paris. Two weeks earlier, in Milan, Armani had staged his first catwalk show since the Covid-19 pandemic hit, showcasing his Spring/Summer 2022 menswear line. Sixteen months earlier, in February 2020, Armani – presciently – was the first Italian designer to cancel a physical show over concerns for health. And a week after we meet he turns 87.

Both Armani’s energy and his appearance – tanned, slender, intense eyes, decisive movements – knock a good quarter-century off any estimate one may give, which, perhaps, connects him more intimately to Emporio than one might

2017 Danish TV series or program

Below the Surface (Danish: Gidseltagningen) is a Danish actionhostagethriller drama television series, written and directed by Kasper Barfoed, that was based upon an idea of Adam Price and Søren Sveistrup. The first eight-part series focuses on an act of terrorism committed on the Copenhagen Metro, where fifteen people are taken hostage. Former soldier Philip Nørgaard (Johannes Lassen [da]), who is head of the PET Terror Task Force (TTF), tries to save the hostages with help from members of his elite team. TTF members are portrayed by Sara Hjort Ditlevsen [da], Alexandre Willaume, Flemming Enevold [da], Esben Dalgaard Andersen [da], Peder Thomas Pedersen [da] and Kenneth M. Christensen.

The basis for the series was adapted from a series of conversations between Barfoed and Danish photographer Daniel Rye, who lived as a hostage within the terrorist organisation of Islamic State in Syria for more than a year. In Germany, the series is known as Countdown Kopenhagen.

On 2 April 2017, the series premiered in Denmark on Kanal 5, and was released on DVD in Germany on 19 October 2017. In the United Kingdom, BBC4 broadcast the first four episodes during March 2018. The BBC pulled the series from their schedule for 24 March only following the terrorist attack in Carcassonne and continued on 31 March. The second season premiered on 26 March 2019 in Denmark. Lassen and his cast mates, except Ditlevsen, reprise their roles as TTF members, which deal with the Elsinore–Helsingborg ferry hijacking by four Islamic terrorists. Hijackers are after foreign fighter June al-Baqee (Yasmin Mahmoud) with Philip as a fellow passenger-hostage.

Plot summary

In Series 1, 15 people are held hostage in a subway train